Spermidine inactivates proteasome activity and enhances ferroptosis in prostate cancer
The elevated polyamines, amine-rich molecules with diverse functions in pathophysiology processes, are implicated in contributing to tumorigenesis and progression.Whether and how they affect the efficacy of chemotherapy is incompletely understood.Our screening assays reveal that the supplement with a low dose of spermidine (Spd), one of the polyami